Phthalazine 1,4-dihydroxy

The silylation-amination of 5,10-dihydroxy-l,4-dioxo-l,2,3,4-tetrahydroben-zo[g]phthalazine 281 for 27 h at 170 °C with excess N(2-aminoethyl)piperidine 282 and HMDS 2 proceeds with catalytic amounts of Ts0H-H20 to afford, via the activated persilylated intermediate in which the sensitive phenolic hydroxy groups are protected, the 1,4-bis-amine 283 in 67% yield. All conventional efforts with POCI3, PCI5, or SOCI2 to convert 281 into the corresponding 1,4-dichloro compound, to be followed by amination, resulted in failure [86] (Scheme 4.35). [Pg.64]

Benzimidazol 1 -Methyl-2-nitrosami-no-E8c, 371 (NH2 - NH-N02) Phthalazine 5,7-Diamino-l, 4-dihydroxy- E9a, 752 [3,5-(NH2)2 —phthalanhydrid/N2H4] Pyrazin 5-Amino-6-cyan-3-metho-xycarbonyl-2-methyl- E9b/2,... [Pg.474]

Phthalazine l,4-Dihydroxy-5,6,7,8-tetrahydro- E9a, 574 (3,4,5,6-H4—phthalanhydrid + N2H4) 2H-Pyran 2-( 3-Diazo-2-oxo-propy 1)-... [Pg.491]

Phthalazine 8-Carboxy-l,4-dihydroxy- E9a, 957 f. (3-OH - 1-oxo-8-COOH — 1,3-H2 — 2-benzofuran/ N2H4)... [Pg.574]

Phthalazine l,4-Dihydroxy-6-methyl- E9a, 752 (subst. Phthalanhydrid/N2H4) Pyrazolidin 3,5-Dioxo-l-phenyl-VII/4, 301... [Pg.591]

Phthalazine l,4-Dihydroxy-5(or 6)-dimethylamino- E9a, 752 (subst. Phthalanhydrid/N2H4) lH-PyrazoI 5-Methyl-5-nitro-4-phenyl-4,5-dihydro- X/l, 426 Pyrido[2,3-d]pyrimidin 4-Hydroxy-2-oxo-l-propyl-1,2-dihydro- E9c,... [Pg.745]

Isophthaisaure 2,6-Dimethyl-4-dimethylamino- -bis-nitriloxid E5, 1591 (aus Bis-oxim) Malonsaure (Amino-benzylamino-methylen)- -methylester-nitril E15/2, 2156 (CC13 - NH-R) I,3i4-Oxadiazol 5-Morpholino-2-phenyl- E8c, 573 (Ar — CO — NH-NH-CO-NR2/POCl3) Phthalazine l,4-Dihydroxy-6-pyrrolidino- E9a, 752 (subst. Phthalanhydrid + N2H4) lH-Pyrazol 5-Carboxy-l-methyl-4-(4-methyl-anilino)- E8b, 633 (4-Br -> 4-NH-Ar)... [Pg.1009]

This type of cyclocondensation is represented only by a somewhat specialized example. Thus methyl p-benzoquinone-2-carboxylate (121) with A-acetonylidene-M-methyDiydrazine (122) gave 4-acetyl-5,8-dihydroxy-2-methyl-l(2Ff)-phthalazi-none (123) [or its tautomer, 4-acetyl-8-hydroxy-2-methyl-l,5(2H,3fl) phthalazine-dione] (MeOH, 20°C, 12 h 50%). °... [Pg.129]

C1sHi0N2O, (1)Benzoxepino[2,3-b]quinoxaline, 44B, 342 C16H10N2O, (3)Benzoxepino[1,2-b]quinoxaline, 44B, 342 C1gHi5CIN2O3, 8-Chloro-4a,14a-epoxy-1,2,3,4,5,14-hexahydrophthal-azino[2,3-b]-phthalazine-7,12-dione, 45B, 342 ClsHi5NO3, cis-4,5-Dihydroxy-3,4-diphenyl-5-methyl-2-isoxazoline, 46B, 382... [Pg.189]

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