Photosensitized Singlet Oxygen Oxidations in Continuous Flow

Photosensitized Singlet Oxygen Oxidations in Continuous Flow 

DeMello et al. reported the use of a microcapillary film (MCF) reactor for the aerobic oxidation of a-terpinene to ascaridole [45]. The MCF was manufactured 

Disulfides play a prominent role in pharmaceuticals, pesticides, and rubber vulcanization reagents. In biological systems, disulfide bonding is essential for peptides and proteins to fold into their active conformation. Noel et al. reported a mild batch and continuous-flow method to access disulfides by the aerobic oxidation of thiols [48]. Initially, an open flask batch procedure with Eosin Y (1 mol%) as catalyst resulted in near quantitative yields for a variety of thiophenols and heteroaromatic and aliphatic thiols, within 16 h. Moreover, it was found that the 

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This chapter provides some highhghts in the innovative field of aerobic oxidation reactions in continuous flow. Topics include transition metal-catalyzed aerobic oxidations in continuous flow, photosensitized singlet oxygen oxidation in continuous flow, metal-free aerobic oxidations in continuous flow, aerobic cou-phng chemistry in continuous flow, and general prospects for scale-up. Ozonolysis is not covered in this chapter hereto, we refer to the literature [25—27]. 

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