Photodynamic therapy tumor regressions

C. Anderson, S. Hrabovsky, Y. McKinley, K. Tubesing, H.P. Tang, R. Dunbar, H. Mukhtar, C.A. Elmets (1997). Phthalocyanine photodynamic therapy disparate effects of pharmacologic inhibitors on cutaneous photosensitivity and on tumor regression. Photochem. PhotobioL, 65, 895-901. 

Kataoka and coworkers recently evaluated the importance of the PEG corona for photodynamic therapy and verified the dependence of light-sensitive polymers on primary tumor accumulation [144]. A porphyrazine derivative was encapsulated in BVqMAA copolymers (polybutadiene-block-poly(l-methyl-2-vinyl pyridinium methyl sulfate)-block-poly(metacrylic add)). The nanoparticles were then PEGylated by electrostatic interaction between MAA and the poly-L-Lysine PEG copolymer. This resulted in better stability in blood, tumor accumulation and tumor regression after irradiation of PEGylated porphyrazine-loaded micelles over im-PEGylated micelles. 

Anderson, C., Hrabovsky, S., McKinley, Y., Tubesing, K., Tang, H.-R, Dunbar, R., Mukhtar, H., and Ehnets, C.A., Phthalocyanine photodynamic therapy disparate effects of pharmacologic inhibitors on cutaneous photosensitivity and on tumor regression, Photochem. Photobiol, 65,895,1997. Simkin, G., Obochi, M., Hunt, D.W.C., Chan, A.H., and Levy, J.G., Effect of photodynamic therapy using benzoporphyrin derivative on the cutaneous immune response, in Optical Methods Jbr Tumor Treatment and Detection Mechanisms and Techniques in Photodynamic Therapy TV, Proc. SPIE, 2392, 23, 1995. 

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