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Phosphoribosyl formylglycineamide

Ribosylamine phosphate Phosphoribosyl glycineamide Phosphoribosyl formylglycineamide... [Pg.101]

The reactions of phosphoribosyl formylglycineamide were considered in detail by Levenberg and Buchanan. A crude pigeon liver extract would convert phosphoribosyl formylglycineamide to inosinate in the presence of... [Pg.106]

Phosphoribosyl formylglycineamidine synthetase catalyzes the irreversible transfer of the amide group of glutamine to phosphoribosyl formylglycineamide to form the corresponding amidine. The molecular weight of the Salmonella typhimurium and chicken liver enzymes is 135,000 21). [Pg.107]

Glutamine binds to the free enzyme with release of the amide nitrogen and probable formation of a 7-glutamyl complex (22). A complex with MgATP and phosphoribosyl formylglycineamide can also be formed, and Mizo-buehi et al. (23) concluded that a covalent bond is formed between the... [Pg.107]

Fig. 15-16 The de novo purine biosynthetic pathway. Rib-5-P, ribose 5-phosphate P-Rib-PP, 5-phosphoribosyl 1-pyrophosphate PRA, 5-phosphoribosylamine IO-CHO-FH4, /Vl0-formyl tetrahydrofolate GAR, glycineamide ribotide FGAR. /V-formylglycineamide ribotide FGAM, /V-formylglycineamidine ribotide AIR, 5-aminoimidazole ribotide CAIR, 4-carboxy-5-aminoimidazole ribotide SAICAR, iV-succino-5-aminoimidazole-4-carboxamide ribotide AICAR, 5-aminoimidazole-4-carboxamide ribotide FAICAR, 5-formamidoimidazole-4-carboxamide ribotide sAMP, /V-succino-AMP. Enzymes (1) amido phosphoribosyltransferase (2) GAR synthetase (3) GAR transformylase (4) FGAM synthetase (5) AIR synthetase (6) AIR carboxylase (7) SAICAR synthetase (8) adenylosuecinase (9) AICAR transformylase (10) IMP cyclohydrolase (11) sAMP synthetase (12) adenylosuecinasc (13) IMP dehydrogenase (14) GMP synthetase. Fig. 15-16 The de novo purine biosynthetic pathway. Rib-5-P, ribose 5-phosphate P-Rib-PP, 5-phosphoribosyl 1-pyrophosphate PRA, 5-phosphoribosylamine IO-CHO-FH4, /Vl0-formyl tetrahydrofolate GAR, glycineamide ribotide FGAR. /V-formylglycineamide ribotide FGAM, /V-formylglycineamidine ribotide AIR, 5-aminoimidazole ribotide CAIR, 4-carboxy-5-aminoimidazole ribotide SAICAR, iV-succino-5-aminoimidazole-4-carboxamide ribotide AICAR, 5-aminoimidazole-4-carboxamide ribotide FAICAR, 5-formamidoimidazole-4-carboxamide ribotide sAMP, /V-succino-AMP. Enzymes (1) amido phosphoribosyltransferase (2) GAR synthetase (3) GAR transformylase (4) FGAM synthetase (5) AIR synthetase (6) AIR carboxylase (7) SAICAR synthetase (8) adenylosuecinase (9) AICAR transformylase (10) IMP cyclohydrolase (11) sAMP synthetase (12) adenylosuecinasc (13) IMP dehydrogenase (14) GMP synthetase.
FGAR, 5 -phosphoribosyl Ai-formylglycineamide FTHF, A/ -formyl-tetrahydrofolate GAR, 5-phosphoribosylglycineamide hCys, homocysteine MTHF, 5-methyl-THF Q, quinone such as... [Pg.38]

See other pages where Phosphoribosyl formylglycineamide is mentioned: [Pg.73]    [Pg.104]    [Pg.104]    [Pg.106]    [Pg.106]    [Pg.111]    [Pg.318]    [Pg.73]    [Pg.104]    [Pg.104]    [Pg.106]    [Pg.106]    [Pg.111]    [Pg.318]   
See also in sourсe #XX -- [ Pg.101 ]



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