Phosphoribosyl glycineamide formyltransferase

Purine biosynthesis de novo was one of the hrst areas of metabolism in which a folic acid derivative was specifically identified as a cofactor in an enzymatic reaction. The ability of pigeon liver extracts to add formate to phosphoribosyl glycineamide was impaired by treatment with charcoal, but was restored by addition of H4-folate. Although the complicated interconversions of the Hrfolate coenzymes (see Chapter 5) caused confusion for some time, the specific one-carbon donor for this reaction was eventually identified as 5,10-methenyl H4-folate. The phosphoribosyl glycineamide formyltransferase reaction itself is irreversible. 

Phosphoribosyl glycineamide formyltransferase Carbon-nitrogen One-carbon transfer No No... 

Phosphoribosyl-AT-formyl-glycineamide tetrahydro-folate 5,10-formyl transferase Phosphoribosyl glycineamide formyltransferase... 

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