Pyruvate Phosphoenol carboxykinase

The oxidative decarboxylation reaction above is part of the TCA cycle and leads to the formation of oxaloacetate, which maybe used to synthesize citrate (with acetyl-CoA) or may be used as a substrate by phosphoenol pyruvate carboxykinase, PEPCK. It should be noted that the phosphoenolpyruvate generated by PEPCK reaction shown above is... 

Glucose-6-phosphatase defect Fructose-1,6-biphosphatase defect Phosphoenol pyruvate carboxykinase defect... 

Fukumoto, S. (1985). Pyruvate kinase isoenzymes and phosphoenol-pyruvate carboxykinase during development of Spirometra erinacei. Yonago Acta Medica, 28 89—105. 

Urbina, J. A., Osorno, C. E. and Rojas, A. (1990) Inhibition of phosphoenol pyruvate carboxykinase from Trypanosoma (Schizotrypanum) cruzi epimastigotes by 3-mercap-topicolinic acid in vitro and in vivo studies. Arch. Biochem. Biophys. 282 91-99. 

Phosphoenol pyruvate carboxykinase and pyruvate carboxylase are the major anaple-rotic enzymes supplying the precursor for the aspartate family of amino acids. Engineering of these two enzymes resulted in redirecting the anaplerotic flux toward the amino... 

Forest C, Tordjman J, Glorian M, Duplus E, Chauvet G, (Juette J, Beale EG, Antoine B (2003) Fatty acid recycling in adipocytes a role for glyceroneogenesis and phosphoenol-pyruvate carboxykinase. Biochem Soc Trans 31 1125-1129... 

T. Ferkol, G.L. Lindberg, J. Chen, J.C. Perales, D.R. Crawford, O.D. Ratnoff, R.W. Hanson, Regulation of the phosphoenol pyruvate carboxykinase/human factor IX gene introduced into the livers of adult rats by receptor-mediated gene transfer,FASEB J. 7 (1993) 1081-1090. 

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