Phosphatidylinositols mass spectrometry

B. C. Berk, R. Aebersold and M. A. Corson, Identification of flow-dependent endothelial nitric-oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the phosphatidylinositol 3-kinase inhibitor LY294002. J Biol Chem 274, 30101-30108 (1999). 

Figure 8 The composition of individual molecular species of phosphatidylinositol in mammalian surfactants as determined by mass spectrometry. Reproduced with permission from Postle AD, Heeley EL, and Wilton DC (2001) Comparative Biochemical Physiology,...

Fig. 10.9. Nanoparticle-asslsted laser desorption/ionization improves spatial resolution in imaging mass spectrometry. (Left panel) Optical image of rat hippocampus indicating measurement area for nanoparticle-based IMS. Nissl-stained section indicating fine layer structure of rat hippocampus is also shown. (Rlgtrtpanel) Ion images which reveal hippocampal layer-specific distribution of phosphatidylinositol (18 0/20 4) at m/z885.5 and sulfatide (24 1) at m/z 888.8 were presented. GCL = granular cell layer, IML = inner molecular layers, MML = middle molecular layers. Reprinted from Ref. (9).

Hsu, F.-F. and Turk, J. (2000) Characterization of phosphatidylinositol, phosphatidylinositol-4-phosphate, and phosphatidylinositol-4,5-bisphosphate by electrospray ionization tandem mass spectrometry A mechanistic study. J. Am. Soc. Mass Spectrom. 11, 986-999. 

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