Phosphatidylinositol 5-kinase regulation

Lee, J.M., Hanson, .M., et ah, Phosphatidylinositol 3-kinase, not extracellular signal-regulated kinase, regulates activation of the antioxidant-responsive element in IMR-32 human neuroblastoma cells, J. Biol. Chem., 276, 20011-20016, 2001. 

Kang, K.W., Lee, S.J., et al., Phosphatidylinositol 3-kinase regulates nuclear translocation of NF-E2-related factor 2 through actin rearrangement in response to oxidative stress. Mol. Pharmacol., 62, 1001-1010, 2002. 

Boudot, C., Kadri, Z., Petitfrere, E., Lambert, E., Chretien, S., Mayeux, P., Haye, B., and Billat, C. Phosphatidylinositol 3-kinase regulates glycosylphos-phatidylinositol hydrolysis through PLC-gamma (2) activation in erythropoietin-stimulated cells. Cell Signal, 2002, 14, 869-878. 

Phosphatidylinositol kinase is involved in the PI turnover pathway and may be important for the regulation of phosphatidylinositol 4,5-bisphosphate levels. Therefore, we... 

Knall C, Worthen GS, Johnson GL. Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases. Proc Natl Acad Sci U S A 1997 94(7) 3052-3057. 

Sulpice E, Bryckaert M, Lacour J, Confreres JO, Tobelem G. Platelet factor 4 inhibits FGF2-induced endothelial cell proliferation via the extracellular signal-regulated kinase pathway but not by the phosphatidylinositol 3-kinase pathway. Blood 2002 100(9) 3087-3094. 

Kim JH, Na HJ, Kim CK, Kim JY, Ha KS, Lee H, Chung HT, Kwon HJ, Kwon YG and Kim YM. 2008. The non-provitamin A carotenoid, lutein, inhibits NF-KB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-KB-inducing kinase pathways role of H2O2 in NF-kB activation. Free Radic Biol Med 45(6) 885-896. 

FIGURE 14-6 Main signaling pathways for histamine receptors. Histamine can couple to a variety of G-protein-linked signal transduction pathways via its four different receptors. The Hj receptor activates the phosphatidylinositol turnover via Gq/11 proteins. The other receptors either positively (H2 receptor) or negatively (H3 and H4 receptor) regulate adenylyl cyclase activity via Gs and GUo protein activation respectively. Several additional signaling pathways have been described, which are not shown. Abbreviations PfP2, phosphatidylinositol 4,5-bisphosphate PIC, phospholipase C AC, adenylyl cyclase ATP, adenosine triphosphate cAMP, cyclic AMP PKC, protein kinase C PICA, protein kinase A. 

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