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Sphingosine 1-phosphate phosphatase

Sphingosine phosphate phosphatases (Sgppl, Sgpp2) Lipid phosphate phosphatases (Ppap2a, Ppap2b)... [Pg.163]

Lipid phosphate phosphohydrolases (LPPs), formerly called type 2 phosphatidate phosphohydrolases (PAP-2), catalyse the dephosphorylation of bioactive phospholipids (phosphatidic acid, ceramide-1-phosphate) and lysophospholipids (lysophosphatidic acid, sphingosine-1-phosphate). The substrate selectivity of individual LPPs is broad in contrast to the related sphingosine-1-phosphate phosphatase. LPPs are characterized by a lack of requirement for Mg2+ and insensitivity to N-ethylmaleimide. Three subtypes (LPP-1, LPP-2, LPP-3) have been identified in mammals. These enzymes have six putative transmembrane domains and three highly conserved domains that are characteristic of a phosphatase superfamily. Whether LPPs cleave extracellular mediators or rather have an influence on intracellular lipid phosphate concentrations is still a matter of debate. [Pg.693]

SIP is formed from sphingosine by sphingosine kinases (SphKs). Degradation of SIP occurs either reversibly by lipid phosphate phosphohydrolases (LPPs) and SIP phosphatases (SPPs), or irreversibly by SIP lyase (SPL) (Fig. 1). The localization of SIP production is highly important since SIP plays a role both as extracellular mediator and as intracellular... [Pg.710]

Mandala, S.M., 2001, Sphingosine l-phosphate phosphatases. Prostaglandins Lipid Mediators 64 143-156. [Pg.264]

Moore, A.N., Kampfl, A.W., Zhao, X., Hayes, R.L. and Dash, P.K., 1999, Sphingosine 1-phosphate induces apoptosis of cultured hippocampal neuronsthat requires protein phosphatases and activator protein-1 complexes, 94 405-415. [Pg.265]

Van Veldhoven, P.P. and Mannaerts, G.P., 1994, Sphinanine 1-phosphate metabohsm in cultured skin fibroblasts evidence for the existence of a sphingosine phosphatase, Biochem. J. 299 597-601. [Pg.267]

Fig. 12. Some signaling targets and pathways affected by sphingolipid backbones that are metabolically interrelated. PKA, protein kinase A PDKl, 3-phosphoinositide-dependent kinase 1 SDKl, sphingosine-dependent kinase 1 PKC, protein kinase C PPl, protein phosphatase 1 PP2A, protein phosphatase 2A aSMase, acid sphingomyelinase PLA, phospholipase Aj SIP, sphingosine-l-phosphase MATIA, methionine adenosyl-transferase (liver specific) SFl, steroidogenic factor 1. The biophysical properties of ceramides and ceramide 1-phosphates may play important roles in membrane structure, including tendencies to form rafts, membrane curvature, and leakiness. Fig. 12. Some signaling targets and pathways affected by sphingolipid backbones that are metabolically interrelated. PKA, protein kinase A PDKl, 3-phosphoinositide-dependent kinase 1 SDKl, sphingosine-dependent kinase 1 PKC, protein kinase C PPl, protein phosphatase 1 PP2A, protein phosphatase 2A aSMase, acid sphingomyelinase PLA, phospholipase Aj SIP, sphingosine-l-phosphase MATIA, methionine adenosyl-transferase (liver specific) SFl, steroidogenic factor 1. The biophysical properties of ceramides and ceramide 1-phosphates may play important roles in membrane structure, including tendencies to form rafts, membrane curvature, and leakiness.
See other pages where Sphingosine 1-phosphate phosphatase is mentioned: [Pg.148]    [Pg.162]    [Pg.163]    [Pg.163]    [Pg.277]    [Pg.148]    [Pg.711]    [Pg.245]    [Pg.245]    [Pg.711]    [Pg.910]    [Pg.1769]    [Pg.1779]    [Pg.1949]    [Pg.26]    [Pg.28]    [Pg.136]    [Pg.136]    [Pg.396]    [Pg.487]    [Pg.517]    [Pg.218]    [Pg.260]    [Pg.61]    [Pg.141]    [Pg.318]   
See also in sourсe #XX -- [ Pg.86 , Pg.87 , Pg.88 , Pg.89 ]



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