Phosphane derivatives

The /.5-phosphanes derived from l-aryl(or heteroaryl)-2,2,2-trichloroethanols are even more stable and are converted into fluorides 12 only on heating above 100 C.18... 

Si-SiCE/glass-silane-phosphane derivative Azide-carbohydrates 52... 

Both observed the monoaddition products 30, but the phosphanediols 31 have been found only by Roschenthaler (227). While the methylated compound 31b decomposes above 45°C, the phosphane derivative 31a has been found to be air-stable. Dimethylphosphane was claimed by Bruker and co-workers (43) to yield the alcohol 32a, which could not be confirmed (227). Instead, the oxidation product 33a has been found together with a diphosphane 34 and fluorophosphorane 35 (227). 

The reaction of triphenyl-/ -phosphanes with carbonyl compounds, the Wittig olcfmation reaction, involves addition to the carbonyl carbon in a reaction closely related to the aldol condensation. Triphenyl-2 -phosphanes, derived from alkyltriphenylphosphorus salts, react with 1,1,1-trifluoroacetonc or other trifluoromethyl ketones " - to give products 29. 

Organolithium compounds can also react with fluorinated phosphorus derivatives. For example, aryl(difluoio)phosphanes 18 are formed by reaction of the corresponding aiyllithium compounds with phosphorus chloride difluoridc. The overall reaction is shown in Table I. This procedure has also been extended to the preparation of several cyclopentadienyl(di-fluoro)phosphane derivatives. ... 

Further examples of the addition of substituted phosphane derivatives to carbonyl groups are presented in Table 11. 

Table 11. Addition of Phosphane Derivatives to Carbonyl Compounds...

Carbonyl Compound Phosphane Derivate Additon Product Yield (%) Ref... 

Complexes 25a-25c contain a benzimidazolylidene NHC ligand coordinated to a gold(I) center as well as a second coordinated ligand, which is chlorido, triphenylphosphane, or the same NHC structure [100]. Interestingly, the cationic biscarbene derivative 25c is a substantially weaker inhibitor of TrxR than the neutral chlorido complex 25a and the cationic phosphane derivative 25b. However, both cationic complexes have higher cytotoxic activity than the neutral 25a. For the cationic complexes, an enhanced cellular uptake with an increased... 

CH3)2BN(CH3)]2P(S)CH3 has been used as a starting material for the preparation of the corresponding 1,3,2,4-diazaphosphaboretidine by thermal elimination of trimethylborane [18]. The same is true for the following bis(borylamino)phosphane derivatives ... 

The modified cobaItoctene hydroformylation using phosphanes derived from limonene was investigated at 170°C and 85bar H2 CO = 2 l. The composition of cobalt complexes in the reaction mixtures was deduced from IR and NMR spectra and correlated to the products of the hydroformylation reaction 7]. 

Theil A, Hitce J, Retailleau P et al (2006) A synthetic approach to macrocyclic, chiral phosphane derivatives with crown-ether-like stmctures. Eur J Org Chem 154-161... 

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