Phi-screen

Phylogenetic screening has been used successfully to isolate retroelements that have been active in recent evolutionary time. In a phi-screen of the white-footed mouse, Peromyscus leucopus, the retrovirus-like element mys was identified by virtue of its hybridization to Peromyscus DNA but its lack of hybridization to Mus (the outgroup) DNA.13 In a phi-screen of human DNA using Galago as an outgroup, both the 5 end of the LI element and the retrovirus-like element THE 1 hybridized differentially,... 

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