Aromatic interactions

Using Charge Schemes to Study Aromatic-Aromatic Interactions... 

Burley SK, Petsko GA. Aromatic-aromatic interactions a mechanism of protein structure stabilization. Science 1985 229 23-28. 

Anderson DE, Hurley JH, Nicholson H, Baase WA, Mathews BW Hydro-phobic core repacking and aromatic-aromatic interaction in the thermostable mutant of T4 lysozyme Ser 117-Phe. Protein Sci 1993 2 1285-1290. 

Serrano L, Bycroft M, Fersht AR. Aromatic-aromatic interactions and protein stability. Investigation of double mutant cycles. J Mol Biol 1990 218 465-475. 

Since hydrophobic interactions contribute largely to the DHFR-inhibitor binding, it was deemed interesting to apply ab initio methods to the description of aromatic-aromatic interactions. 

Aromatic side chains of amino acids such as phenylalanine, tryptophan, and tyrosine are found in general in the interior of proteins, in hydrophobic regions. In some proteins they mediate helix-helix contacts. It is to be expected that agents containing aromatic groups could interact with proteins via aromatic-aromatic interactions, as for instance, proven by X-ray studies of biphenyl compounds which inhibit sickle-cell hemoglobin gelation. 

Jorgensen, W. L. Severance, D. L., Aromatic-aromatic interactions free energy profiles for the benzene dimer in water, chloroform and liquid benzene, J. Am, Chem. Soc. 1990, 112, 4768 1774. 

Burley, S. K., and Petsko, G. A. (1986). Amino-aromatic interactions in proteins. FEBS Lett. 203, 139-143. 

E. C. Stanca Kaposta, D. P. Gamblin, J. Screen, B. Liu, L. C. Snoek, B. G. Davis, and J. P. Simons, Carbohydrate molecular recognition A spectroscopic investigation of carbohydrate aromatic interactions. Phys. Chem. Chem. Phys. 9, 4444 4451 (2007). 

Horak, J., Maier, N.M., and Lindner, W., Investigations on the chromatographic behavior of hybrid reversed-phase materials containing electron donor-acceptor systems ii. Contribution of pi-pi aromatic interactions, J. Chromatogr. A, 1045, 43, 2004. 

Burley, S.K. and Petsko, G.A. Aromatic-aromatic interaction a mechanism of protein stmcture stabilization. Science. 1985, 229, 23-28. 

Porat Y, Abramowitz A, Gazit E (2006) Inhibition of amyloid fibril formation by polyphenols structural similarity and aromatic interactions as a common inhibition mechanism. Chem Biol Drug Des 67 27-37... 

Stepnowski, R, Nichthauser, Mrozik, W., and Buszewski, B., Usefulness of jt- -n aromatic interactions in the selective separation and analysis of imidazolium and pyridinium ionic liquid cations. Anal. Bioanal. Chem., 385, 1483-1491,2006. 

Figure 10. The specific structure of flux-promoting compound 6. S3 anchors to the membrane surface through N -aromatic interaction and the hydrophobic Si locates in the interior membrane, thereby spanning the oxyethylene part S2. ...

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