5-Phenylmercaptoacetic acids

The QODC oxidation of 5-phenylmercaptoacetic acids in H2O-ACOH-HCIO4 has an inverse first-order dependence in H+ ions. Electron-withdrawing substituents enhance the rate, whereas electron-releasing substituents have the opposite effect increase in rate with decreasing dielectric constant suggests the involvement of a dipole in the rate-limiting step. This research is published by the same authors in two different journals. ... 

There are more routes to cyclization. Phenylmercaptoacetic acid may be replaced by its o-carboxy or o-amino derivative to form the thionaphthenone-3. The first reaction is performed in molten alkali, the second proceeds via diazotization, Sandmeyer reaction with sodiumcyanide/copper cyanide, alkaline hydrolysis, and acid treatment. 

Dichlorothiophenol is treated with chloroacetic acid to form 2,5-dichloro-phenylmercaptoacetic acid. Cyclization followed by oxidation with chlorosulfonic acid at 35°C affords 4,7-dichlorothionaphthenone-3. Direct addition of bromine in chlorosulfonic acid without separating the intermediate yields the 4,4, 1,1 -tetrachlorothioindigo derivative through oxidative dimerization. It is also possible to separate the monoheterocycle and to oxidize it with oxygen in an alkaline medium. 

Phenyl mercaptan. See Thiophenol Phenyl mercaptoacetic acid S-Phenylmercaptoacetic acid. See Phenylthioglycolic acid Phenylmercaptotetrazole. See 1-Phenyl-5-mercaptotetrazole 1 -Phenyl-5-mercaptotetrazole CAS 86-93-1 EINECS/ELINCS 201-710-5 Synonyms Mercaptophenyltetrazole 5-Mercapto-1 -phenyltetrazole ... 

Phenyl thioacetic acid 2-(Phenylthio) acetic acid. See Phenylthioglycolic acid Phenylthioglycolic acid CAS 103-04-8 EINECS/ELINCS 203-073-9 Synonyms Acetic acid, (phenylthio)- Phenyl mercaptoacetic acid S-Phenylmercaptoacetic acid Phenyl thioacetic acid 2-(Phenylthio) acetic acid PTG... 

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