Phenylethylbarbituric acid

Phenylethylbarbituric acid (also termed luminal and phenobarbitone) may be prepared by condensing ethyl phenyletUylmalonate with urea in the presence of sodium methoxide ... 

P-Phenylethyl alcohol, 812,816 Phenylethylene, 1015,1024 a-Phenylethylamine, 560, 566 P-Phenylethy,amine, 560, 567,569 Phenylethylbarbituric acid, 1003,1005 P-Phenylethyl bromide, 283 P-Phenylethyl iodide, 288 Phenylglycine-o-carboxylic acid, 980 Phenylglyoxal, 866 Phenylhydrazine, 635, 636 hydrochloride, 636, 637 Phenylhydrazine acetate reagent, 343, 721 ... 

Common Name Phenobarbital Fenemal Fenobarbital Fenobarbiton Phenylethylbarbituric acid... 

PHENYLETHYL ANTHRANILATE see APJ500 PHENYLETHYLBARBITURATE see EOKOOO PHENYL-ETHYL-BARBITURIC ACID see EOKOOO 5-PHENYL-5-ETHYLBARBITURIC ACID see EOKOOO PHENYLETHYLBARBITURIC ACID, SODIU.M SALT see SIDOOO... 

Fischer s purine research also was of interest to the German chemical industiy. His laboratory methods became the basis for the industrial production of cafeine, theophylline, and theobromine. In 1903, he i thesized 5,5-diethylbarbituric acid. Under various trade names -Barbital, Veronal, and Dorminal - this compound proved to be a valuable h3rpnotic. Another commercially valuable purine was phenylethylbarbituric acid prepared by Fischer in 1912 and known as Luminal or Phenobarbital (4). 

After nitration, phenylethylbarbituric acid (phenobarbital) can be determined in the presence of a hundredfold excess of diethyl-barbituric acid (barbital). 

Barbital and other 5,5-dialkylbarbituric acids gave the well-developed waves, whereas the wave of phenobarbital is ill-developed. The determination of barbiturates is prevented by substitution of hydrogen in the NH group as in N-methyl-5,5-phenylethylbarbituric acid. 

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