3-Phenylethy.amine

P-Phenylethyl alcohol, 812,816 Phenylethylene, 1015,1024 a-Phenylethylamine, 560, 566 P-Phenylethy,amine, 560, 567,569 Phenylethylbarbituric acid, 1003,1005 P-Phenylethyl bromide, 283 P-Phenylethyl iodide, 288 Phenylglycine-o-carboxylic acid, 980 Phenylglyoxal, 866 Phenylhydrazine, 635, 636 hydrochloride, 636, 637 Phenylhydrazine acetate reagent, 343, 721 ... 

Woodruff, E., H. Conger, T.,W. Physiologically Active Phenethylamines. I. Hydroxy and Methox3 -o/p/ia-mcthy]-phenylethy]amines (B-phenylisopropyl-aminos Journal of the American Chemical Society (1938) 60 465-467. 

Interestingly, all other diols, tried as a protecting group on the acetal, led to lower diastereoselectivity of the addition. This synthetic strategy was used in the synthesis of indolizidine alkaloids,279 bis(l-arylethyl)amines,280 a protease inhibitor.281 The addition reaction of 1,2-bisimines, easily available from glyoxal and chiral cr-phenylethy-lamine, gives under optimized conditions a diastereomerically pure product, that was converted to a chiral 1,2-diamine. Interestingly, decrease of the temperature below the optimum (50 °C) leads to a sharp drop of the stereoselectivity (Scheme 96).282... 

SYNS P-AMINOETHYLBENZENE l-AMINO-2-PHENYLETHANE p-PHENYLAETHYLAMIN (GERMAN) 1-PHENYL-2-AMINO-AETHAN (GERMAN) 1-PHENYL-2-AMINOETHANE PHENYLETHYL-AMINE (B-PHENYLETHYLAMINE 2-PHENYLETHY-LAMINE... 

A number of amines produced in cheese are biologically active, including tyramine, histamine, tryptamine, putrescine, cadaverine, and phenylethy-lamine. These biogenic amines can have imporant physiological effects for susceptible individuals, including migraine headaches and hypertension (see Section IXJ). 

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