Phenprocoumon Rifampicin

Held H. Interaktion von Rifampicin mit Phenprocoumon Beobachtungen bei tuberkulosekranken Patienten. [Interaction of rifampicin with phenprocoumon.] Dtsch Med Wochenschr 1979 104(37) 1311-14. 

In a study in healthy subjects, rifampicin 600 mg daily for 14 days increased the clearance of a single dose of phenprocoumon by 2.2-fold. Similarly, two patients stabilised on phenprocoumon required the dose to be doubled while taking rifampicin 600 mg daily (plus isoniazid with or without ethambutol). In one case, the patient developed severe gross hae-maturia 3 months after rifampicin had been discontinued because the phenprocoumon dose had not been reduced. ... 

Ohnhaus EE, Kampschulte J, Monig H. Effect of propranolol and rifampicin on Uver blood flow and phenprocoumon elimination. Acta Pharmacol Toxicol (Coper4i) (1986) 59 (Suppl... 

An isolated case report describes a marked reduction in the effects of warfarin, which was attributed to teicoplanin, but which could be equally be explained by rifampicin treatment. One study found that vancomycin possibly causes a small increase in the effects of warfarin, and a cohort study suggested that vancomycin increased risk of over-anticoagulation with acenocoumarol or phenprocoumon. 

---

See also in sourсe #XX -- [ ]

---