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Phenotypic-based drug discovery

As target resolution increases, the mechanism of action in drug discovery has become much more complex. Assay development methods have used molecular biology techniques to keep pace. Cells expressing recombinant proteins can act as biosensors for real-time analysis of target inhibition in the cell instead of relying on traditional cytotoxicity. These target-, rather than phenotypic-, based assays permit... [Pg.113]

Normal and patient-derived iPSC-based phenotypic drug discovery... [Pg.355]

See other pages where Phenotypic-based drug discovery is mentioned: [Pg.228] [Pg.63] [Pg.228] [Pg.63] [Pg.99] [Pg.30] [Pg.352] [Pg.63] [Pg.722] [Pg.10] [Pg.128] [Pg.2] [Pg.585] [Pg.7] [Pg.251] [Pg.274] [Pg.157] [Pg.1] [Pg.97] [Pg.518] [Pg.338] [Pg.136] [Pg.163] [Pg.164] [Pg.256] [Pg.585] [Pg.152] [Pg.231] [Pg.3] [Pg.21] [Pg.193] [Pg.11] [Pg.366] [Pg.149] [Pg.7] [Pg.356] [Pg.320] [Pg.345] [Pg.751] [Pg.3] [Pg.483] [Pg.482] [Pg.97] [Pg.193] [Pg.234] [Pg.82] [Pg.353] [Pg.355] [Pg.356]

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Phenotype

Phenotype/phenotyping

Phenotypic

Phenotyping