Phenolics Hydroxy group concentration

K from the measured average frequencies. At room temperature and concentrations in the 1 M range, oligomerization with n = 3 is predominant . At concentrations in the 10 M range, formation of P2 species appears to be the preferred oligomerization, as determined by IR measurements . In the solid phase the phenol hydroxy groups form extended linear chains . 

Bisphenols are composed of two phenolic groups connected by various linkages. Hydroxy halogenated derivatives, such as hexachlorophane (Fig. 10.7D) and triclosan, are the most active microbiologically, but are bacteriostatic at use-concentrations and have little antipseudomonal activity. The use of hexachlorophane is also limited by its serious toxicity. Both hexachlorophane and trichlosan have limited application in medicated soaps and washing creams. 

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