Phenobarbital Dicumarol

Clinically important, potentially hazardous interactions with adefovir, alprazolam, amprenavir, anisindione, anticoagulants, buprenorphine, carbamazepine, dicumarol, dihydroergotamine, ergot, fosamprenavir, indinavir, ixabepilone, lovastatin, methadone, methysergide, midazolam, phenobarbital, phenytoin, quinidine, rifabutin, rifampin, sildenafil, simvastatin, triazolam, warfarin... 

Clinically important, potentially hazardous interactions with amlodipine, anisindione, anticoagulants, aprepitant, atorvastatin, barbiturates, benzodiazepines, butabarbital, carbamazepine, chlordiazepoxide, clarithromycin, clonazepam, dorazepate, corticosteroids, cyclosporine, dexamethasone, diazepam, dicumarol, erythromycin, ethotoin, felodipine, flurazepam, fluvastatin, fosphenytoin, isradipine, itraconazole, ketoconazole, lorazepam, lovastatin, mephenytoin, mephobarbital, midazolam, nicardipine, nifedipine, nimodipine, nisoldipine, oxazepam, pentobarbital, phenobarbital, pimozide, pravastatin, primidone, quazepam, rifampin, secobarbital, simvastatin, St John s wort, temazepam, warfarin... 

Clinically important, potentially hazardous interactions with aluminum, aminophylline, aspirin, chlorambucil, cimetidine, clarithromycin, cyclophosphamide, cyclosporine, dicumarol, diuretics, docetaxel, estrogens, grapefruit juice, indomethacin, influenza vaccines, itraconazole, ketoconazole, lansoprazole, live vaccines, methotrexate, montelukast, omeprazole, oral contraceptives, pancuronium, phenobarbital, phenytoin, ranitidine, rifampicin, rifampin, timolol, tolbutamide, vitamin A... 

Cucinell, S. A., Conney, A. H., Sansur, M., and Burns, J. J. (1965) Drug interactions in man. I. Lowering effect of phenobarbital on plasma levels of bishydrox-ycoumarin (dicumarol) and diphenylhydantoin (dilantin). Clin. Pharmacol. Ther. 6, 420 129. 

Noninterfering dicumarol, phenylbutazone, ethacrynic acid, glyburide, hydrochlorothiazide, niacin, phenobarbital, propoxyphene, diazepam... 

Cucinell SA, Conney AH, Sansur H Bums JJ. Drug interactions in man I. Lowerm effect of phenobarbital on plasma levels of bishydroj coumarin (Dicumarol) and diphenylhydantoin QDilantin). Clin Pharmacol Ther (1965) 6,420-9. 

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