Phenobarbital Antipyrine

Elovaara, E., Engstrom, K., Hayri, L., Hase, T. Aitio, A. (1989) Metabolism of antipyrine and OT-xylene in rats after prolonged pretreatment with xylene alone or xylene with ethanol, phenobarbital or 3-methylcholanthrene. Xenobiotica, 19, 945-960... 

Rapaport and Solyanik (168) have developed a rapid method of refractometric determination of 23 mixtures containing anesthesin, barbamyl, bromcamphor, bro-misoval, camphor, antipyrine, amidopyrine, acetalsali-cylic acid, barbital, codeine, salol, terpin hydrate, hexamethylenetetramine, and phenobarbital. The method described is suitable for analysis of pharmaceutical mixtures containing compounds which are insoluble in water and soluble in ethanol. A mixture of 2 pharmaceuticals (0.1 g) is dissolved in 1 ml. ethanol and np of this solution is determined. One component is... 

Much of the evidence, however, is based on prolonged plasma half-lives of drugs that are metabolized totally or mainly by hepatic micrasomal enzymes (e.g antipyrine, phenobarbital, acetaminophen). In evaluating the effect of age on drug metabolism, one must differentiate between normal" loss of enzymatic activity with aging and the effect of a disea.sed iiver from hepatitis, cirrhosis, etc., plus decreased renal function, becau.se much of the water-soluble conjugation products are excreted in the liver. 

Vesell ES, Page JG. 1969. Genetic control of the phenobarbital-induced shortening of plasma antipyrine half-lives in man. J. Clin. Invest. 48 2202-9... 

Also analyzed acebutolol, acepromazine, acetaminophen, acetazolamide, acetophenazine, albuterol, alprazolam, amitriptyline, amobarbital, amoxapine, antipyrine, atenolol, atropine, azatadine, baclofen, benzocaine, bromocriptine, brompheniramine, brotizolam, bupivacaine, buspirone, butabarbital, butalbital, caffeine, carbamazepine, cetirizine, chlorcyclizine, chlordiazepoxide, chlormezanone, chloroquine, chlorpheniramine, chlorpromazine, chlorpropamide, chlorprothixene, chlorthalidone, chlorzoxazone, cimeti-dine, cisapride, clomipramine, clonazepam, clonidine, cocaine, codeine, colchicine, cycli-zine, cyclobenzaprine, dantrolene, desipramine, diazepam, diclofenac, diflunisal, dil-tiazem, diphenhydramine, diphenidol, diphenoxylate, dipyridamole, disopyramide, dobutamine, doxapram, doxepin, droperidol, encainide, ethidium bromide, ethopropazine, fenoprofen, fentanyl, flavoxate, fluoxetine, fluphenazine, flurazepam, flurbiprofen, fluvox-amine, furosemide, glutethimide, glyburide, guaifenesin, haloperidol, homatropine, hydralazine, hydrochlorothiazide, hydrocodone, hydromorphone, hydroxychloroquine, hydroxyzine, ibuprofen, imipramine, indomethacin, ketoconazole, ketoprofen, ketorolac, labetalol, levorphanol, lidocaine, loratadine, lorazepam, lovastatin, loxapine, mazindol, mefenamic acid, meperidine, mephen5rtoin, mepivacaine, mesoridazine, metaproterenol, methadone, methdilazine, methocarbamol, methotrexate, methotrimeprazine, methox-amine, methyldopa, methylphenidate, metoclopramide, metolazone, metoprolol, metronidazole, midazolam, moclobemide, morphine, nadolol, nalbuphine, naloxone, naphazoline, naproxen, nifedipine, nizatidine, norepinephrine, nortriptyline, oxazepam, oxycodone, ox-ymetazoline, paroxetine, pemoline, pentazocine, pentobarbital, pentoxifylline, perphenazine, pheniramine, phenobarbital, phenol, phenolphthalein, phentolamine, phenylbutazone, phenyltoloxamine, phenjrtoin, pimozide, pindolol, piroxicam, pramoxine, prazepam, prazosin, probenecid, procainamide, procaine, prochlorperazine, procyclidine, promazine, promethazine, propaJfenone, propantheline, propiomazine, propofol, propranolol, protriptyline, quazepam, quinidine, quinine, racemethorphan, ranitidine, remoxipride, risperidone, salicylic acid, scopolamine, secobarbital, sertraline, sotalol, spironolactone, sulfinpyrazone, sulindac, temazepam, terbutaline, terfenadine, tetracaine, theophylline, thiethylperazine, thiopental, thioridazine, thiothixene, timolol, tocainide, tolbutamide, tolmetin, trazodone, triamterene, triazolam, trifluoperazine, triflupromazine, trimepra-zine, trimethoprim, trimipramine, verapamil, warfarin, xylometazoline, yohimbine, zopiclone... 

Lurie, I.S. McGuiness, K. The quantitation of heroin and selected basic impurities via reversed phase HPLC. II. The analysis of adulterated samples. J.Liq.Chromatogn, 1987, 10, 2189-2204 [UV detection electrochemical detection also acetaminophen, acetylcodeine, acetylmorphine, acetylprocaine, aminopyrene, amitriptyline, antipyrine, aspirin, barhital, benztropine, caffeine, coceiine, diamor-phine, diazepam, diphenhydramine, dipsrone, ephedrine, ethylmorphine, lidocaine, meconin, meth-amphetamine, methap3rrilene, methaqualone, morphine, nalorphine, niacinamide, noscapine, papaverine, phenacetin, phenmetrazine, phenobarbital, phenolphthalein, procaine, propanophenone, propoxyphene, pyrilamine, quinidine, quinine, salicylamide, saliqrlic acid, secobarbital, strychnine, tartaric acid, tetracaine, thebaine, tripelennamine, tropacocaine, vitamin B3, vitamin B5]... 

Lurie, I.S. Demchuk, S.M. Optimization of a reverse phase ion-pair chromatographic separation for drugs of forensic interest. I. Variables affecting capacity factors. J.Liq.Chromatogn, 1981, 4, 337-355 [acetylcodeine, acetylmorphine, aminopyrene, aminopyrine, amobarbital, antipyrine, butabarbital, diamorphine, methapyrilene, morphine, narcotine, papaverine, pentobarbital, phenobarbital, quinidine, quinine, secobarbital, strychnine, thebaine]... 

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