Phencyclidine nervous system

Zukin, S.R., and Zukin, R.S. Specific 3H phencyclidine binding in rat central nervous system. Proc Nat Acad Sci USA 76 5372 -5376, 1979. 

Lazdunski, M. Interaction of phencyclidine with the muscarinic and opiate receptors in the centra 1-nervous system. Rra in Res 152 176-182, 1978. 

Balster, R.L., and Wessinger, W.D. Central nervous system depressant effects of phencyclidine. In Kamenka. J.M. Domino. 

List of Abbreviations Ach, acetylcholine AMPA, a-amino-3-hydroxy-5-methylisoxazole-4-propionic acid CNS, central nervous system COMT, catechol-O-methyltransferase DA, dopamine DRP-2, dihy-dropyrimidinase-related protein 2 DSM, diagnostic and statistical manual of mental disorders GNAS1, guanine nucleotide-binding protein (G-protein) alpha stimulating activity polypeptide 1 5-HIAA, 5-hydroxyindole acetic acid 5-FIT, serotonin (5-hydroxytryptamine) MAO, monoamine oxidase MHPG, 3-methoxy-4-hydroxyphenylglycol NE, norepinephrine NMDA, N-methyl-D-aspartate PCP, phencyclidine SSRI, selective serotonin reuptake inhibitor SDS, schedule for the deficit syndrome... 

Figure 4.4 This is a schematic representation of the N-methyl-D-aspartate (NMDA) receptor. Both ketamine and phencyclidine block the flow of ions through this receptor, which causes their effects on the central nervous system.

CNS, central nervous system DA, dopamine 5-HT, serotonin LSD, lysergic acid diethylamide MAOl, monoamine oxidase inhibitor NE, norepinephrine PCP, phencyclidine ... 

CNS Central nervous system CVS Cardiovascular system CIT Gastrointestinal tract LSD Lysergic acid diethylamide PCP Phencyclidine... 

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