1,10-Phenanthroline-copper complex, tetramethyl

However, treatment with inorganic copper was not as effective as therapy with copper complexes. A single 5 mg/kg dose of Cu(II)(dimethylglyoxime)2 increased the life-span of mice bearing Ehrlich ascites or Sarcoma 180 tumours 2- to 3-times that of non-treated controls [358]. Other copper complexes reported to have similar antitumour activities in rodents are Cu(II)(3,4,7,8,-tetramethyl-1,10-phenanthroline) [360], Cu(IIX2-keto-3-... 

Substituted bipyridines and phenanthrolines have been used as ligands for copper(II) ions. 4,4 6,6 -Tetramethyl-2,2 -bipyridyl(L) gives monomeric CuL(N03)2, two sulfato complexes, and a series [CuL2X]+C104, as well as forming copper(I) complexes readily (309). 2,9-Dimethyl-1,10-phenanthroline affords 1 1 complexes with cupric... 

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