Phenanthrene hexahydro

C17H21CIN2O4 59639-73-5) see Vincamine (135-cis)-13-ethyl-7,ll,12,13,16,17-hexahydro-3-methoxy-6//-cycIopenta[a]phenanthren-17-oI acetate ( 22112 03 2911-81-1) see Levonorgestrel 3-ethylhexahydro-3-(3-methoxyphenyl)-lH-azepine (C15H23NO 27180-90-1) see Meptazinol... 

Nitrogen heterocycles continue to be valuable reagents and provide new synthetic approaches such as NITRONES FOR INTRAMOLECULAR -1,3 - DIPOLAR CYCLOADDITIONS HEXAHYDRO-1,3,3,6-TETRAMETHYL-2,l-BENZISOX AZOLINE. Substituting on a pyrrolidine can be accomplished by using NUCLEOPHILIC a - sec - AM IN O ALKYL ATION 2-(DI-PHENYLHYDROXYMETHYL)PYRROLIDINE. Arene oxides have considerable importance for cancer studies, and the example ARENE OXIDE SYNTHESIS PHENANTHRENE 9,10-OXIDE has been included. An aromatic reaction illustrates RADICAL ANION ARYLATION DIETHYL PHENYLPHOSPHONATE. 

Diphenic acid (17) and its ester as well as ci s-hexahydro-2,2 -diphenic acid (18) are all hydrogenated largely to give cw- yn-aT-perhydro derivatives over platinum oxide in acetic acid, in the same stereochemical manner as do its anhydride and the phenanthrene derivatives related to it (Scheme 11.12).198,199 Linstead et al. explained the results on the assumption that the diphenic acid or its ester are hydrogenated in the coiled form (17a), rather than in the zigzag form (17b), which is expected to yield the product with a cis-anti-cis configuration.62... 

Preparation of (1,3,4,6,7,8-hexahydro-2H-5-oxa-l-aza-phenanthren-6-yl)-6-carboxylic acid ethyl ester... 

Table 1 Selected 1,3,4,6,7,8-hexahydro-2H-5-oxa-l-aza-phenanthren-6-yl derivatives and their corresponding physical properties. R- and S-enantiomers were prepared using either the (.R)- or (S )-[2-(f-butyl-(dimethyl-silanyloxy-methyl)-8-methyl-chroman-7-yl]-carbamic acid f-butyl ester in Step 1...

Polycyclic aromatic hydrocarbons, such as anthracene and phenanthrene, can be reduced at elevated temperatures (80°C) at constant current to different hydroderivatives in an aqueous medium containing (TBA )OH (2.1 M). The following products were obtained in yields depending on the number of FmoP and the cell construction 9,10-dihydroanthracene, hexahydro-, octahydro-, and decahydroanthracenes. Phenanthrene can be reduced under similar conditions no isomerization step is necessary to obtain octahydro- and decahydrophenanthrene [43,51]. 

Michaelides, M.R. Hong, Y. DiDomenico, S., Jr. Asin, K.E. Britton, D.R. Lin, C.W. Williams, M. Shiosaki, K. (1995) (5aR,llbS)-4,5,5a,6,7,llb-hexahydro-2-propyl-3-thia-5-azacyclopent-l-ena[c]-phenanthrene-9, 10-diol (A-86929) a potent and selective dopamine Di agonist that maintains behavioral efficacy following repeated administration and characterization of its diacetyl prodrug (ABT-431). J. Med. Chem. 38, 3445-3447. 

Aus der Viclzalil der nur intermediar auftretenden 4a,4b-Dihydro-phenantlirene sind 10b, 10c-Dihydro- (dibenzo-[c g]-phenanthren ) (1) 2>3 und 3,6-Dioxo-9,10-diathyl-3,4,4a,4b,5,6-hexahydro-ph nan-thren (II)1 als isolierbare Verbindnngen hervorzuheben. 

There are many synthetic examples that use radical cyclization as a key step, and the radical precursor is not limited to iodides or bromides. In Pattenden s synthesis of pentalenene, conjugated selenyl ester 156 was treated with Bu3SnH and AIBN to give a 45% yield of tricyclic ketone 159. Loss of PhSe generated the acyl radical 157, which exists in equilibrium with the ketene radical 156. Radical cyclization via the latter intermediate leads to 159. Cyclization via aryl radicals is also possible. In Schultz s synthesis of hexahydro-phenanthren-2-one derivatives, " aryl bromide 160 was cyclized to 161 in 78% yield under standard conditions. Radical cascade reactions have become quite popular for the synthesis of polycyclic ring systems. In these reaction, polyenes are subjected to radical cyclization, generating tricyclic or even tetracyclic ring systems. 5 Chiral auxiliaries have been used effectively in radical cyclization reactions. ... 

Diels-Alder condensation of 3,4-dihydro-5,6,7-trimethoxy-l-vinylnaphth-l-ol (299) with methyl acrylate afforded the isomeric hexahydro-6,7,8-trimethoxy-phenanthrene-2a-carboxylic acids (300) and (301). The acid (300) was readily... 

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