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Pharmacology orexins

Case Study 3 Deorphanizing Receptors by Reverse Pharmacology (Orexins and CPCRs)... [Pg.369]

Significantly, orexin/ataxin-3 mice respond to intracerebroventricular injection of orexin-A with increased wakefulness and suppression of REM sleep and cataplexy. This pharmacological reversal indicated that orexin receptors remain functional in the absence of orexin neurons, and that these narcoleptic mice can respond to orexin agonists, a finding with significant therapeutic implications (Mieda et al., 2004b). [Pg.414]

Watanabe S, Kuwaki T, Yanagisawa M, Fukuda Y, Shimoyama M (2004) Persistent pain and stress activate pain-inhibitory orexin pathways. NeuroReport 16 5-8 Webb TI, Lynch JW (2007) Molecular pharmacology of the glycine receptor chloride channel. CurrPharmDes 13 2350-2367... [Pg.530]

T. Sakurai, Reverse pharmacology of orexin from an orphan GPCR to integrative physiology, Regul. Pept. 2005, 126, 3-10. [Pg.383]

See other pages where Pharmacology orexins is mentioned: [Pg.908]    [Pg.912]    [Pg.912]    [Pg.913]    [Pg.166]    [Pg.199]    [Pg.450]    [Pg.71]    [Pg.141]    [Pg.227]    [Pg.433]    [Pg.908]    [Pg.912]    [Pg.912]    [Pg.913]    [Pg.872]    [Pg.886]    [Pg.111]    [Pg.369]    [Pg.947]   


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Orexin pharmacology

Orexins

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