Pharmacology gabapentin

Pharmacology Gabapentin is an oral antiepileptic agent. The mechanism by which it exerts its anticonvulsant and analgesic actions is unknown. 

Outside of the evidence-based guidelines, other pharmacologic treatments are commonly used or avoided. For initial treatment of absence seizures, ethosuximide and valproate are commonly used, not only in the United Kingdom, but also in the United States. Zonisamide may be also used for initial treatment of absence and myoclonic seizures. In absence and myoclonic seizures, carbamazepine, oxcarbazepine, gabapentin, tiagabine, and pregabalin should be avoided, as they have been associated with an exacerbation of these types of seizures. 

Goa KL, Sorkin EM. Gabapentin. A review of its pharmacological properties and clinical potential in epilepsy. Drugs 1993 46(3) 409-27. 

Peripheral neuropathy is also common with advanced CKD and is typically indistinguishable from other types of neuropathy (e.g., diabetic neuropathy). Symptoms are often uncomfortable for the patient and prompt many clinicians to initiate pharmacologic therapy in an attempt to reduce these symptoms. Tricyclic antidepressants (e.g., amitriptyline) and anticonvulsants (e.g., phenytoin and gabapentin) may have some benefit in alleviating symptoms of neuropathy however, risks and benefits must be considered for agents... 

Pharmacologic treatment of RLS includes dopaminergic agents, benzodiazepines, opioids, or anticonvulsants. In mild cases of RLS, benzodiazepines may be first-line agents. Clonazepam, lorazepam, triazolam, and temazepam have been effective. Clonazepam 0.5 to 2 mg is most frequently studied. Opiates such as methadone 5 to 20 mg, codeine 30 to 120 mg, and oxycodone 2.5 mg are very effective, but the development of tolerance is a concern. Abuse potential with opiates is also a concern due to the chronic nature of the condition. Other agents that have been used include apomorphine, amantadine, tramadol, magnesium, oxycodone, propoxyphene, gabapentin, bromocriptine, clonidine, and carbamazepine. Tolerance may de-... 

Granados-Soto V, Argtielles CF. Synergic antinociceptive interaction between tramadol and gabapentin after local, spinal and systemic administration. Pharmacology (2005) 74, 200-8. 

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