Pharmacology criteria

Serotonin receptors. Based on biochemical and pharmacological criteria seven receptor classes can be distinguished. Of major pharmacotherapeutic importance are those designated 5-HTi, 5-HT2,5-HT4, and 5-HT7, all of which are G-protein-coupled, whereas the 5-HT3 subtype represents a ligand-gated non-selective cation channel. 

As noted previously, three major classes of opioid receptors ( -, 5, and ) have been identified in various nervous system sites and in other tissues (Table 31-1). Each of the three major receptors has now been cloned. All are members of the G protein-coupled family of receptors and show significant amino acid sequence homologies. Multiple receptor subtypes have been proposed based on pharmacologic criteria, including 14, v-2, 1, 52 and k2, and k3. However, genes encoding... 

All intoxication cases described above demonstrate clearly that safety evaluation of pharmacologically active compounds to which consumers are exposed as residues in food must be based on both toxicological and pharmacological criteria. Consumption of 100 g liver containing clenbuterol in concentration levels as determined in liver samples contaminated with 160-500 ppb, would exceed the pharmacological effect level of 5 g per person (47). 

Arch defines the P3-receptor using pharmacological criteria... 

De Ponti, F. (1997) Pharmacological criteria for the detection of ps-adrenoceptors. Trends Pharmacoi Sci, 18, 52-53. 

Adrenergic receptors can be subdivided in al,a2 and P fi2 receptors on the basis of pharmacological criteria (Bylund and Pritchard, 1983 Minneman et al., 1981). Most... 

The final demonstration of receptor-specific binding of the radioligand in vivo should be subject to the same pharmacological criteria as in vitro. Namely, binding should be saturable, stereoselective and displaceable. 

Characterization of Q-type Ca channels is mostly based on pharmacological criteria. As described, Q-type channels are resistant to blockade by DHPs, co-conotoxin GVIA, and low doses (<100 nM) of co-agatoxin IVA, but they are sensitive to co-conotoxin MVIIC (1-3 pM). Increasing concentrations of co-agatoxin IVA (up to 2 pM) can also block Q-type Ca channels [80]. It should... 

HTg receptors have been identified mainly using the pharmacological criteria defined by Bradley et al. [73] 1) They should be resistant to blockade by antagonists at 5-HT,-like, 5-HTg (and S-HTJ receptors 2) they should be responsive to PBG and 2-methyl-5-HT (but unresponsive to 5-methoxy-tryptamine) 3) they should be blocked by low concentrations of bemesetron, tropisetron (and the other specific 5-HTg antagonists, mainly zacopride and granisetron). Thus, 5-HTg receptors were found exclusively on neuronal membranes in the periphery and CNS. 

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