Pharmacokinetics interrelationships

F. Lokiec, J.P. Armand, and J. Robert. 1997. Pharmacokinetic interrelationships ofirinotecan (CPT-11) and its three major plasma metabolites in patients enrolled in phase I/II trials. Clin. Cancer Res. 3 1261-1266. 

FIGURE 4.1 Schematic representation of the interrelationship between drug input (dosage), pharmacokinetics (concentration), pharmacodynamics, and clinical effects. 

The acetylation of isoniazid and acetylhydrazine are both subject to genetic variability, so the production and detoxication pathways are both influenced by the acetylator phenotype. The hepatotoxicity of isoniazid is therefore dependent on a complex interrelationship between genetic factors and individual variation in the pharmacokinetics of isoniazid. Studies of the pharmacokinetics of acetylhydrazine in human subjects after a dose of isoniazid have revealed that although the peak plasma concentration of acetylhydrazine is higher in rapid acetylators, when the plasma concentration of acetylhydrazine is plotted against time, the area under the curve... 

Periti, P., and Mazzei, T. (1999). Clarithromycin Pharmacokinetic and pharmacodynamic interrelationships and dosage regimen. / Chemother. 11, 11-27. 

Piotrovskii, V. K., Model and model-independent methods of describing pharmacokinetics the advantages, drawbacks and interrelationship, Antibiot. Med. BiotekhnoL, 32 492 97, 1987. 

To provide further appreciation for the hepatic extraction ratio and its interrelationship with other pharmacokinetic parameters, we introduce the following physiological approach. 

Factors which influence the most complete delivery of drug substances at the desired rate in the intended form and their interrelationship with each other, with body disposition and with observed pharmacologic response constitute areas of interest among researchers in pharmaceutics, biopharmaceutics and pharmacokinetics. 

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