Pharmacokinetics abbreviations used

The term toxicokinetics is used to describe the time-dependent fate of a substance within the body. This includes absorption, distribution, metabolism, and/or excretion. (EC 2003). The term, often abbreviated ADME, has essentially the same meaning as pharmacokinetics, but the latter term should be restricted only to pharmaceuticals. 

Bullets show properties predicted in each of the reported software. The following abbreviations are used solubility (Sol), membrane permeability (Perm), transporters (Trp), human intestinal absorption (Fa), pharmacokinetic properties (PK). 

Throughout this chapter, abbreviations for various pharmacokinetic parameters are used frequently. Commonly used abbreviations are listed in Table 5-2. 

Figure 15.9 The use of dosing rate (R) and the corresponding steady-state plasma concentrations to obtain the pharmacokinetic parameters for a drug that exhibits non-linear kinetics. Abbreviations as in Fig. 15.7.

An important feature of drug development is the estimation of pharmacokinetic parameters in animal models. Pharmacokinetics is the study of the time dependence and mechanism of absorption of a compound dosed into the body, its distribution throughout the fluids and other body tissues, the sequential metabolic transformations of the compound and its first-generation metabolites, and the elimination of the original compound and its metabolites (whence the common abbreviation ADME studies). The usual experimental raw data consist of concentrations of the test compound (and sometimes of its metabolites) in body tissues and body fluids (blood plasma, urine) as a function of time following a single dose. Extraction of quantitative parameters characterizing this behavior is determined by the theoretical model used to interpret the data. For example, if the dose is administered intravenously and the compound concentrations are measured in the blood, there will be an immediate drop of compound concentration with time as the compound is re-distributed, metabolized and excreted, but if an oral dose is used (as... 

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