Pharmacogenetics goals

NIH goals for the PGRN, http //www.nigms.nih.gov/pharmacogenetics/ goals.html. 

A major goal of pharmacogenetic and pharmacogenomic analyses in early-phase clinical studies is to identify subpopulations of subjects with an improved safety and efficacy profile. However, there are various views on how pharmacogenetics and pharmacogenomics could be used in the design of clinical trials. Some examples are as follows ... 

The goal of this review is to summarize the current state of knowledge in the area of pharmacogenetics of human transporters known to be involved in drug disposition. The molecular, biochemical, and physiological role of each transporter will be systematically outlined (Table 1) as well as the functional relevance of genetic polymorphisms in such transporters (Tables 2 and 3, www.vanderbilt.edu/kimlab). 

The ultimate research goal of transporter pharmacogenetics is to further our understanding of the ways in which transporter genetics influences clinical endpoints so that current drug treatment can be made safer and more efficacious, and investigational therapies can be better developed. The literature consists of a multitude of studies that have evaluated drug efficacy and toxicity and have... 

The goals of pharmacogenetics are to optimize drug efficacy and limit drug toxicity based on an individual s DNA. 

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