Pharmacodynamics 23 pages

A traditional isostere, or classical isostere, is an atom or group of atoms with similar spatial requirements (Table 11.4, page 281).10 Exchanging one for another imparts little change on the shape and volume of the molecule and therefore should not affect the binding (pharmacodynamics) of a compound. Changing one isostere for another, however,... 

Tozer, T.N. and Rowland, M., 2006, Introduction to pharmacokinetics and pharmacodynamics The quantitative basis of drug therapy, Lippincott Williams Wilkins (326 pages, paperback). 

The pharmacodynamic properties of the ergot alkaloids cover a relatively broad spectrum of activity which can be classified as in the accompanying tabulation (see next page). 

The most abundant member of this group is the cannabinoid Al-THC-7-oic-acid. When tested in humans as well as in the rhesus monkey, this cannabinoid did not show the behavioral activity or the cardiovascular effects characteristic of the parent substance, THC. (Perez-Reyes, M. In Pharmacokinetics and Pharmacodynamics of Psychoactive Drugs, Barnett, G. and Chiang, N. (eds), Biomedical Press, 1985, pages 287-310 Mechoulam, R. and Edery, M. ln Marijuana, Mechoulam, R. (ed.), Academic Press, New York, 1973). Thus, little attention has been given to the possible pharmacodynamic properties of this metabolite or any of the other acid metabolites of THC. 

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