Pharmacodynamics Hill equation

Although the maximum-effect pharmacodynamic models are empirically based/ they do incorporate the concept of a maximum effect predicted by the drug-receptor interactions described earlier. The Hill equation/ which takes the same form as the equation describing drug effect as a function of receptor occupancy/ relates a continuous drug effect to the drug concentration at the effect site as shown ... 

Once the concentration is known at the effector site, a pharmacodynamic model is used to describe its action. Saturation may need to be built into the effect, as well as a possible threshold concentration. Hill s sigmoidal equation can accommodate both ... 

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