Pharmacodynamic therapy acids

All ergot alkaloids which have so far been used therapeutically are lysergic acid derivatives. Representatives of the second main group, the clavine alkaloids, have also been found to be pharmacodynamically active, but as yet, none has been found to exert effects that can be utilized in therapy. The uterotonic and sympatholytic actions are less prominent in their pharmacological spectra of activity but, for example, elymoclavine and agroclavine have a pronounced central excitatory action which is attributed to their stimulation of sympathetic centers (172). 

In 2008, a Phase lib study of bevirimat in patients failing HIV therapy due to drug resistance was completed successfully. The results of this study demonstrated that patients who have virus with the most commonly occurring amino acids at positions 369, 370, or 371 on Gag are much more likely to respond to bevirimat treatment. In contrast, those patients whose virus has polymorphisms (variants) at these positions are less likely to respond to the drug. Furthermore, pharmacokinetic/pharmacodynamic modelling demonstrated that a trough plasma concentration of greater than 20 pg/mL bevirimat is required for a robust response. 

Used as an antidote to folic acid antagonists such as methotrexate, q.v which block the conversion of folic acid into folinic add. Review of clinical combination therapy with methotrexate J. R. Bertino et al, Ann. N.Y. Acad, Sci. 186,486-495(1971). Pharmacokinetics, pharmacodynamics P. F, Nixnu, Clin. Exp. Pharmacol. Physiol... 

Successful treatment of acid-related diseases is significantly correlated with suppression of 24-h gastric acid secretion [28-30]. Three key parameters which determine the effect of treatment with antisecretory drugs have been identified through a series of meta-analyses of pharmacodynamic gastric secretory studies and clinical therapeutic trials the degree of suppression of acid secretion, the duration of acid suppression over the 24-h period and the length of therapy in weeks [28-30]. 

Vicent, D., Villanueva-Penacarrillo, M.L., et al. (1994) In vivo stimulation of insulin release by succinic acid methyl esters. Archives Internationales de Pharmacodynamic et de Therapie, 327,246-250. 

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