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Pharmaceuticals embryotoxicity

The rabbit is generally the non-rodent species or second species after the rat recommended by the regulatory authorities and is part of the package of regulatory reproductive studies for the detection of potential embryotoxic and/ or teratogenic effects of pharmaceuticals, chemicals, food additives, and other compoimds, including vaccines (see Chapters 1-7). [Pg.139]

Frog embryo teratogenesis assay on Xenopus (FETAX) has been routinely used in oiu laboratory for the last 12 years as a routine developmental toxicity screening test for pharmaceutical candidate compoimds. To date, out of more than 400 candidates tested in FETAX, around 60 have also been evaluated in mammalian embryotoxicity studies according to standard ICH protocols. [Pg.403]


See other pages where Pharmaceuticals embryotoxicity is mentioned: [Pg.283]    [Pg.14]    [Pg.153]    [Pg.173]    [Pg.177]    [Pg.685]    [Pg.688]    [Pg.8]    [Pg.1042]    [Pg.177]    [Pg.170]   
See also in sourсe #XX -- [ Pg.3 , Pg.3 , Pg.4 ]

See also in sourсe #XX -- [ Pg.3 , Pg.3 , Pg.4 ]




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Embryotoxic

Embryotoxicity

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