Pharmaceutical solids freeze-drying process

The exclusion of water from the environment of a protein may provide resistance to chemical modification of the protein structure during processing and storage. Processes such as freeze-drying and spray drying have been employed to prepare solid-state dosage forms of pharmaceutical proteins with vastly reduced water content. Several theories of protein encapsulation in glassy materials have been proposed based on the three considerations mentioned in Section 6.4.2.3 ... 

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