Pharmaceutical properties relative order

Irrespective of administration route, sustained-release profiles or even zero-order drug release profiles are often required of the active pharmaceutical ingredients, in order to maintain relatively consistent plasma concentrations. Biotextiles as DDSs achieve the required sustained-release characteristics mainly by virtue of the physico-chemical properties of polymers when the active ingredients are dissolved or dispersed within the matrices. This can also be accomplished because of their particular structure, for example when the fibers are employed as drug reservoirs in the core/shell. Most of the biotextiles mentioned are designed to achieve sustained drug delivery. 

Among the neutron-deficient isotopes of Tc, " Tc seems to have suitable nuclear properties for application in positron emission tomography (PET) (Browne and Firestone 1986). Considering the relatively new lipophilic Tc-labeled flow tracers used in cardiac perfusion imaging (2-methoxyisobutyl isocyanide [MlBl], teboroxime, tetrofosmin) it would be reasonable to replace Tc with " Tc in order to carry out quantitative investigations of biodistribution and clearance with PET. With this replacement, the pharmacokinetics of useful Tc compounds could be studied in a number of cases, which would enhance the introduction of new Tc-labeled pharmaceuticals into clinical practice. The labeling and quality control methods are well known and partly subject of this book. Our task is to review the different methods for the production of Tc and also the separation technique from irradiated targets. 

Co-crystals represent a novel class of crystalline solids which possess scientific and regulatory advantages along with enormous intellectual property potential. In the earlier stages of pharmaceutical process development, an efficient cocrystal screening is essential in order to determine the different possible stoichiometries and the different polymorphic forms for each stoichiometry. When all the different phases are identified, the relative stability of the solid phases in solution has to be determined. This step requires the construction of the... 

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