Pharmaceutical analysis microemulsion electrokinetic chromatography

Altria, K. D. (1999). Application of microemulsion electrokinetic chromatography to the analysis of a wide range of pharmaceuticals and excipients.. Chromatogr A 844, 371—386. 

Tu, J., Halsall, H.B., Seliskar, C.J., Limbach, P.A., Arias, F., Wehmeyer, K.R. and Heineman, W.R. (2005) Estimation of logP(ow) values for neutral and basic compounds by microchip microemulsion electrokinetic chromatography with indirect fiuorimetric detection (muMEEKC-IED). Journal of Pharmaceutical and Biomedical Analysis, 38, 1-7. 

H. Huang, Y. C. Lai, C. W. Chiu, J. M. Yeh, Comparing micellar electrokinetic chromatography and microemulsion electrokinetic chromatography for the analysis of preservatives in pharmaceutical and cosmetic products./. Chromatogr. A, 2003, 993, 153-164. 

After a short introduction into the relevance of Impurity profiling for regulatory authorities, public health, and the pharmaceutical industry, an overview is presented based on the various modes of capillary electrophoresis that have been used in drug impurity analysis. The applications of capillary zone electrophoresis, non-aqueous capillary electrophoresis, micellar electrokinetic capillary chromatography, microemulsion electrokinetic capillary chromatography, capillary gel electrophoresis, and capillary electrochromatography are presented consecutively. 

Several modes of CE have been described in the literature over past decade [6, 7], The most common are open tubular or capillary zone electrophoresis (CZE), micellar electrokinetic chromatography (MEKC), microemulsion elec-trokinetic chromatography (MEEKC), capillary electrochromatograpy (CEC), capillary gel electrophoresis, capillary isoelectric focusing and capillary iso-tachophoresis. Three recent reviews by Watzig [113], Tagliaro etal. [114] and Riekkola etal. [115] summarise the current method development options available to manipulate selectivity. In pharmaceutical analysis, CZE, MEKC, MEEKC and CEC are commonly used. 

Chapter 19 Microemulsions as Pseudostationary Phases in Electrokinetic Chromatography I. Estimation of Physicochemical Parameters. II. Analysis of Drugs in Pharmaceutical and Biofluidic Matrices.501... 

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