Phage display structure activity

Forrer, P., Jung, S., and Pluckthun, A. (1999). Beyond binding using phage display to select for structure, folding and enzymatic activity in proteins. Gun. Opin. Biotechnol. 9, 514-520. 

The structure of p53 in complex with hdm2 [40] and the initial data obtained with p53-derived peptides [36, 39] indicate that peptides can be used to study this interaction to establish a pharmacophore model. Phage display experiments [47] allowed the identification of a 12-mer phage-derived peptide (peptide 2, Table 15.5-2) that is 29 times more potent than the wild-type peptide (peptide 1, Table 15.5-2) [48], Peptide 2 was truncated to eight residues, leading to a peptide with micromolar activity (peptide 3, Table 15.5-2) [48]. It should... 

Pannekoek H, van Meijer M, Schleef RR, Loskutoff DJ, Barbas CD, Functional display of human plasminogen-activator inhibitor I (PAI-1) on phages Novel perspectives for structure-function analysis by error-prone DNA synthesis, Gene, 128 135-140, 1993. 

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