Perphenazine sulfoxide

N. Beauliew and E. G. Lovering, Liquid chromatographic method for perphenazine and its sulfoxide in pharmaceutical dosage forms for determination of stability, J. Assoc. Off. Anal. Chem., 69 16 (1986). 

Simultaneous alprazolam, chlorpromazine, chlorprothixene, clomipramine, desmethyli-mipramine, diazepam, flunitrazepam, fluphenazine, haloperidol, imipramine, maproti-line, perphenazine, promethazine, protriptyline, thioridazine, thioridazine sulfone, thioridazine sulfoxide, zimeldine, zuclopenthixol... 

Sackett and McCreery " " have measured the observed second-order rate constants for reaction of a number of phenothiazine cation radicals. Some typical values in phosphate buffer at pH 3.7 are shown in Table 4. The cation radicals shown in this table all give rise to equimolar yields of sulfoxide and parent phenothiazine. However, the kinetics of decay of the cation radicals of chlorpromazine, promazine, triflupromazine, nori chlorpromazine, and nor2 chlorpromazine are qualitatively the same whereas in the case of the cation radicals of methoxypromazine and acepromazine the decays are qualitively different. The cation radicals generated from promethazine (6), fluphenazine (7), perphenazine (8), and chlorphenethazine (9) did not give rise to equal yields of the sulfoxide and parent phenothiazine, but give lower yields of the... 

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