Perphenazine dosage

With the use of major tranquillisers, for example, thioridazine, chlorpromazine, or perphenazine, it is possible to withdraw opiate dependents who are highly motivated. The dosages can be titrated to the degree of clinical symptoms and this can be monitored with key carers through an out-patient clinic. The use of hypnotics should be restricted to short-term use due to their own dependency problems, but they can be a useful addition, particularly in the early phases of the treatment programme. 

N. Beauliew and E. G. Lovering, Liquid chromatographic method for perphenazine and its sulfoxide in pharmaceutical dosage forms for determination of stability, J. Assoc. Off. Anal. Chem., 69 16 (1986). 

A 52-year-old woman developed Meige s syndrome 2 days after the appearance of akathisia. She had taken neuroleptic drugs for years, but her current medication had been changed to bromperidol 18 mg/day and trihexyphenidyl (benzhexol) 6 mg/day 2 days later she developed akathisia. Oral perphenazine 12 mg and trihexyphenidyl 6 mg dose-dependently reduced the frequency of blepharospasm the dosages of bromperidol and trihexyphenidyl were gradually reduced to 8 mg/ day and 3 mg/day respectively over 3 months, by which time her symptoms had completely disappeared. 

Oral perphenazine is less potent than the injection, so patients should receive equal or higher dosage when switched from injection to tablet... 

A comparative study of 99 patients taking amitriptyline or nortriptyline alone, and 60 other patients also taking perphenazine 10 mg daily, found that although the tricyclic antidepressant dosages were the same, the plasma tricyclic antidepressant levels of the perphenazine group were up to 70% higher. ... 

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