Peroxidase inhibition

Nomura, K., Imai H., Koumura T., Kobayashi, T., andNakagawa, Y., 2000, Mitochondrial phosphohpid hydroperoxide glutathione peroxidase inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiohpin in hypoglycaemia-induced apoptosis, Biochem. J. 351 183-193. 

Glutathione peroxidase inhibition. Water extract of the fresh root, administered intragastrically to infant mice at a dose of 50 mL/kg, was active. The treatment was administered for seven successive days followed by a single dose of 20% v/v CCI4 in olive subcutaneously at 1 mL/kg on the last day, 1 hour after the administration of the carrot extract . ... 

From the dose-response curves, potency ratios and confidence limits are calculated. This approach may be modified for short term uptake of 13 I or 1251 as a parameter of thyroid peroxidase inhibition by antithyroid drugs. 

PURPOSE AND RATIONALE Propyl-thiouracil (PTU) and a wide spectrum of drugs may inhibit thyroid hormone synthesis. Some of these drugs can be used for treatment of thyrotoxicosis. As consequence of thyroid peroxidase inhibition, the iodine uptake and content of the thyroid is decreased. This phenomenon is dose-dependent and may occur at lower doses than those increasing thyroid weight in rats (McGinty and Bywater 1945). The historical parameter of iodine content was replaced by measuring uptake and release of radio-iodine (131-1). 

The formation of a reversible Michaelis-Menten-type complex of the enzyme and ferrocytochrome c [ES1S2 in Eq. (3) ] can be postulated from initial steady-state kinetics of the cytochrome c peroxidase reaction (17). Since cytochrome c peroxidase and cytochrome c are acidic and basic proteins, respectively, their interaction may be governed principally by electrostatic attraction. This assumption is further supported by the fact that several polycations which reversibly and irreversibly bind cytochrome c peroxidase inhibit its enzymic activity in competition with ferrocytochrome c 17,62). 

Ishibashi N, Prokopenko O, Weisbrot-Lefkowitz M, Reuhl KR, Mirochnitchenko O (2002) Glutathione peroxidase inhibits cell death and gUal activation following experimental stroke. Brain Res Mol Brain Res 109 34-44... 

Yoshikawa, S., Kayes, S.G. and Parker, J.C. (1993). Eosinophils increase lung microvascular permeability via the peroxidase-hydrogen peroxide-halide system. Bronchoconstriction and vasoconstriction unaflFected by eosinophil peroxidase inhibition. Am. Rev. Respir. Dis. 147, 914-920. 

Green tea and methimazole likewise act on the premise of peroxidase inhibition. 

Superoxide dismutase (SOD), catalases, and peroxidases inhibit oxidation in vivo by inactivating ROS. There are multiple forms of SOD and all contain metal ions, which are integral to die dismutation reaction. For FeSOD, the dismutation is attributed to the following reactions. 

Lipid peroxidase inhibition - in vitro, cone, used not stated, vs. Fe(II)/Ascorbate, CCLi/NADPH or 91... 

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