Permissive hypercapnia

Saghaei M, Mortazavian M. Pulsus alternans during general anesthesia with halothane effects of permissive hypercapnia. Anesthesiology 2000 93(1) 91. ... 

Puybasset, L., Stewart, T., Rouby, J. J., Cluzel, P., Mourgeon, E., Belin, M.-F., Arthaud, M., Landault, C., and Viars, P. (1994b). Inhaled nitric oxide reverses the increase in pulmonary vascular resistance induced by permissive hypercapnia in patients with acute respiratory distress syndrome. Anesthesiology 80, 1254-1267. 

Is the acute reduction in CBF produced by indomethacin in humans, primates, rat, and gerbil a result of inhibition of prostaglandin synthesis in some compartment within the brain If endogenous arachidonic derivatives play more than a permissive role in control of cerebrovascular reactivity, then it should be possible to demonstrate that the changes in concentration of the relevant eicosanoid within the appropriate compartment within the brain should change with, for example, hypercapnia. The problem is how to estimate such eicosanoid levels in the appropriate compartment. Severe insults such as cerebral ischaemia of varying duration do result in the release... 

---