Permeability of Mucous Membranes and Octanol Water Partition Coefficients

2 Permeability of Mucous Membranes and Octanol Water Partition Coefficients 

The relationship between lipophilic membrane permeability and Kow is well described in the literature. Kitagawa, Li, and Sato reported that permeability coefficients across excised skin increased directly with Kow for a homologous series of parabens. As is from the data in Table 3.1, greater permeability is directly related to greater lipophilicity (higher 7T w) J5 

Potts and Guy concluded that lipid properties of chemicals account for permeability through the stratum corneum of the skin and that permeability is a function of the K of a compound. Bowman and Maibach showed 

Siegel studied the permeability of the oral mucosa. He found that in a homologous series, an increase in lipid solubility resulted in an increased permeability of the oral mucosa. His permeation constants correlate exactly with Kow values J7 8  

Scheuplein and Ross reported that skin permeability was increased by treatment with nonpolar solvents. Their data show that permeability constants for a homologous series of alcohols are a function of carbon number, a relationship that corresponds exactly to increasing /ywJ9 These data are shown in Table 3.2. 

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