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Permeability improving with prodrugs

FT, farnesyltransferase GGT-1, geranylgeranyltransferase 1 FTI, farnesyltransferase inhibitor GGTI, geranylgeranyltransferase inhibitor. In experiments with intact cells, methylester prodrugs were used to improve cell permeability. [Pg.144]

Adenine itself was successfully incorporated into a number of pharmaceuticals, Adefovir dipivoxil, also known as bis-POM PMEA, with trade names Preveon and Hepsera, is used for the treatment of hepatitis B and herpes simplex virus infection. It is an orally administered nucleotide analog as a reverse transcriptase inhibitor (NRTI). Reverse transcriptase is an enzyme crucial to viral production. A second NRXI that contains adenine is Tenofovir disoproxil fumarate (TDF), which has been used in the treatment of HIV/AIDS and hepatitis B. TDF is a prodrug of tenofovir (also known as PMPA) designed to improve absorption and cell permeability of the active moiety under the trade name Viread. Both adefovir dipivoxil and TDF are marketed by Gilead Sciences. [Pg.571]

See other pages where Permeability improving with prodrugs is mentioned: [Pg.538]    [Pg.78]    [Pg.218]    [Pg.227]    [Pg.227]    [Pg.361]    [Pg.363]    [Pg.375]    [Pg.287]    [Pg.310]    [Pg.549]    [Pg.215]    [Pg.2]    [Pg.595]    [Pg.299]    [Pg.737]    [Pg.40]    [Pg.41]    [Pg.127]    [Pg.145]    [Pg.231]    [Pg.115]    [Pg.512]    [Pg.658]    [Pg.417]    [Pg.259]    [Pg.486]    [Pg.125]    [Pg.121]    [Pg.124]    [Pg.23]    [Pg.23]    [Pg.1709]   
See also in sourсe #XX -- [ Pg.2 , Pg.674 ]

See also in sourсe #XX -- [ Pg.674 ]



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Permeability prodrugs

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