Peripheral T-cell tolerance

Steinman RM, Nussenzweig MC. Avoiding horror autotoxicus the importance of dendritic cells in peripheral T cell tolerance. Proc Natl Acad Sci U S A 2002 99(1) 351-358. 

Importantly, although Th2 cells are responsible for the development of allergic diseases, Thl cells may contribute to chronicity and effector phase in allergic diseases [30-33,38,39]. Distinct Thl and Th2 2 subpopulations of T cells counterregulate each other and play a role in distinct diseases [34,35]. In addition, recent studies have demonstrated that peripheral T-cell tolerance is crucial for a healthy immune response and successful treatment of allergic disorders [40-42]. A further subtype ofT cells, with immunosuppressive function and cytokine profiles distinct from either Thl and Th2 cells, termed regulatory/suppressor T cells (Treg), has been existence in humans has been demonstrated [41,... 

Peripheral T-Cell Tolerance in Allergen-Specific Immunotherapy... 

Peptide immunotherapy (PIT) is another attractive approach for investigation of peripheral T-cell tolerance in humans. Short allergen peptides, either native sequences or altered peptide... 

Peripheral T-Cell Tolerance to Allergens Is Associated with Regulation of Antibody Isotypes and Suppression of Effector Cells... 

Regulation of Peripheral T-Cell Tolerance and Aberrations in Allergic Diseases... 

Miethke T, Wahl C, Gaus H, Heeg K, Wagner H Exogenous superantigens acutely trigger distinct levels of peripheral T cell tolerance/immunosuppression dose-response relationship. Eur J Immunol 1994 24 1893-1902. 

Fazekas de St Groth B DCs and peripheral T cell tolerance. Semin Immunol 2001 13 311-322. 

Bluestone J. Is CTLA4 a master switch for peripheral T cell tolerance J Immunol 1997 158 1989. 

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