Peripheral kappa agonist

Generic Name peripheral kappa agonist Trade/Proprietary Name CR845 Drug Class opioid analgesic Manufacturer/Developer Cara Therapeutics Parrot Drive, Trumbull, CT... [Pg.490]

Riviere PJ. Peripheral kappa-opioid agonists for visceral pain. Br J Pharmacol. 2004 141 1331-1334. [Pg.197]

Kappa agonists can also produce antinociceptive effects in inflammatory pain through interaction with peripheral k opioid receptors. Kappa agonists have been shown to have anti-... [Pg.355]

Central and peripheral analgesic agents from kappa-opioid agonists 95E405. [Pg.231]

Major and minor sites of action methyinaltrexone is a peripheral opioid-receptor antagonist. It is also a partial agonist at mu, delta, and kappa opioid receptors. [Pg.418]

CR845 is a novel peripherally restricted, all-d-amino acid tetrapeptide kappa opioid selective agonist under development for the treatment of acute and chronic pain. It belongs to a novel class of opioid ligands which has a reduced ability to cross the blood-brain barrier and therefore acts without inducing central side effects [1]. It is currently available as an intravenous formulation in a sterile isotonic 0.04 M acetate buffer of pH 4.5 composed of acetic acid, sodium acetate trihydrate, sodium chloride, and water, with addition of hydrochloric acid for pH adjustments. [Pg.490]