Perineural infiltration

Perineural infiltration around 60min (Kristinsson et al 1996) caudal epidural 90-150 min (Pikes et al 1989, Grubb et al 1992, Le Blanc et al 1988)... 

Anterior stromal infiltrates can develop under the dendritic HZO lesions and appear as hazy, granular, nummular, subepithelial opacities. They have been observed in close proximity to enlarged comeal nerves, which possibly represents a perineuritis from viral destruction of the sensory nerves. These lesions are responsive to topical steroids, indicating they are most likely caused by a local immime reaction to the epithelial dendrites. 

This tumor is the most common neuroendocrine neoplasm of the larynx and accounts for approximately 54% of all tumors.1 " It occurs most frequently in the supraglottic larynx and has a male predominance. Atypical carcinoids have an infiltrative growth and can have variety of morphologic patterns. The cells differ from those of a typical carcinoid in that they are larger and show nucleoli and occasional mitoses. Furthermore, they may exhibit necrosis and vascular or perineural... 

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