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Perindopril

C7HJO 100-51-6) see Fluoxetine Gabapentin Ganciclovir Levocabastine Moexipril Nicotinic acid benzyl ester Perindopril Quinapril hydrochloride Ramipril Saquinavir Trandolapril benzylamine... [Pg.2304]

C jH2,NOSi) see Indanorex (lS-cii)-2,3-dihydro-l//-indene-l,2-diol (G7H10O2 6752S-22-7) see Indinavir sulfate (laS)-la,6a-dihydro-6//-indenori,2-6]oxirene (CgHjO 67528-26-1) see Indinavir sulfate (2,3-dihydro-l//-inden-4-yl)carbamimidothioic acid methyl ester monohydriodide (C, H 1N2S 40507-77-5) see Indanazoline 23-dibydro-l//-indole-2-carboxylic acid ethyl ester (C iH, N02 50501-07-0) see Perindopril... [Pg.2355]

C iH FjNO, J254S3-3I-0) see Dolasetron mesilate indole-3-carboxylic acid imidazolide (CiiHoNjO 99445-26-S) see Tropisetron (S)-indoline-2-carboxylic acid (QjH.jNOj 79815-20-6) see Perindopril ( )-2-(lH-indol-5-yl)-A -methylethenesulfonamide (CiiHijNjOjS 98623-49-5) see Naratriptan 5-(3-indolylmcthyl)hydantoin (Ci2H N,02 21753-16-2) see L-Tryptophan... [Pg.2402]

CjiHiyN iO . 9/022-35-0) see Mosapramine (25, 3a/f,7a5)>octahydro-l//-indole-2-carboxylic acid (C9H15NO2 145438-94-4) see Trandolapril (25,3a5 7a5)-octahydroindole-2-carboxylic acid (CyHi,N02 80875-98-5) see Perindopril [2S-(2a,3aa,7aP)]-octahydro-l/f-indole-2-carboxylic acid phenylmethyl ester... [Pg.2428]

C3H4O3 127-17-3) see Perindopril (2-oxopropyl)phosphonic acid dimethyl ester (C5H),04P 4202-14-6) see Latanoprost 11 -oxo-3-(l-pyrrolidinyl)prcgna-3,5,17(20)-trien-21-oic acid methyl ester... [Pg.2430]

Trandolapril (Mavik) 1-4 (perindopril) Stroke (perindopril + indapamide)... [Pg.19]

Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study European Trial on Reduction of Cardiac Events with Perindopril in Stable Coronary Artery Disease Trial... [Pg.31]

Perindopril Protection Against Recurrent Stroke Study... [Pg.31]

Benetos A, Cambien F, Gautier S et al. Influence of the angiotensin-II type 1 receptor gene polymorphism on the effects of perindopril and nitrendipine on arteri-... [Pg.35]

Perikinetic flocculation, 22 55 Perindopril, molecular formula and structure, 5 15 It Perinone Orange... [Pg.683]

Lactam formation has been documented for a few drugs or drug metabolites. For example, the in vivo formation of a primary lactam metabolite was reported for bromfenac and perindopril. Bromfenac (11.144) is an anti-inflammatory agent, which, in humans and monkeys, is cyclized to the lactam 11.145, the first metabolite to appear in urine [159], At later times post-dose, hydroxylated and conjugated metabolites of 11.145 are excreted. Thus, cy-clization by dehydration appears to be the major if not the sole primary re-... [Pg.738]

In the metabolism of perindopril (11.146, R = Et), in vivo cyclization to the lactam 11.147 (R = Et) was also observed [160], In monkeys, dogs, and rats, hydrolysis of the ethyl ester group predominated, yielding perindopri-late (11.146, R = H). In humans, perindopril lactam (11.147, R = Et) and per-indoprilate lactam (11.147, R = H) were the major metabolites. Such large interspecies differences seem to exclude artifactual formation of the lactams during sample workup. [Pg.739]

The examples of bromfenac and perindopril clearly demonstrate that, given properly positioned amino and carboxylate groups, lactam formation is, indeed, a distinct metabolic possibility. [Pg.739]


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