Perfluoroalkylation reaction

Trifluoromethylation is the most important perfluoroalkylation reaction. The initial work was earned out with trifluoromethyl iodide and copper metal in the... [Pg.700]

An interesting development of this research is the preparation of polymer-supported FITS reagent from bis(trifluoroacetoxy)iodoperfluoroalkanes and Nafion-H [145]. FITS-Nafion reacts with organic substrates that react to usual FITS reagents, but the products of the perfluoroalkylation reaction can be separated easily from the insoluble resin by filtration [145]... [Pg.969]

Trifluoromethylation is the most important perfluoroalkylation reaction. Kobayashi and co-workers reported the trifluoromethylation of aryl, vinyl, alkyl halides with trifluoromethyl iodide in the presence of copper powder in aprotic solvents such as HMPA at 120-150 °C [83,84], and this methodology has been applied to the preparation of fluorinated pyrimidine and purine nucleosides [85,86] (Scheme 27). [Pg.56]

Ma JA, Cahard D (2004) Asymmetric fluorination, trifluoromethylation, and perfluoroalkylation reactions. Chem Rev 104 6119... [Pg.117]

The more general approach to fluoroalkylthiophenes is anionic perfluoroalkylation of 2-bromthiophenes with perfluoroalkyliodides in the presence of copper." " The mechanism of perfluoroalkylation reaction consists of the steps involving the formation of solvated complex of fluoroaUcylcopper, coordination of heterocyclic halide and ligands exchange at copper center. ... [Pg.190]

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