Perez-Castells

A combination of a metathesis and a Pauson-Khand reaction, which leads to tricyclic compounds starting from diene-ynes, has been described by Perez-Castells and colleagues [262]. Treatment of the Co-complex 6/3-86, obtained from the corresponding alkyne in 75 % yield, with 5 mol% of the Ru-catalyst 6/3-13 for 18 h, followed by addition of an N-oxide as trimethylamine-N-oxide (TMANO) or NMO as copromoters, gave 6/3-87 in 81% yield. 

M. Rosillo, L. Casarrubios, G. Dominguez, J. Perez-Castells, Org. Eiomol. 

Perez-Castells, R., Alvarez, A., Gavilanes, J., Lizarbe, M.A., Martinez del Pozo, A., Olmo, N. and Santaren, J. (1987) (eds L.G. Schultz H.vanOlphen, F.A. Mumpton ), Proceedings of the International Clay Conference, Denver, 1985, The Clay Mineral Society, Bloomington, 359—362. 

Perez-Serrano L, Casarrubios L, Dominguez G, Perez-Castells (1999) Org Lett 1 1187... 

Grasillas, A. Perez-Castells, J. Macrocyclization by ring-closing metathesis in the total synthesis of natural products Reaction conditions and limitations. Angew. Chem. Int. Ed. 2006,45, 6086-6101. 

Blanco-Urgoiti, J. Anorbe, L. Perez-Serrano, L. DomAnguez, G. Perez-Castells, J. Chem. Soc. Rev. 2004, 33, 32. 

Perez-Castells J (2006) Cascade Reactions Involving Pauson-Khand and Related Processes. 19 207-258... 

Handbook of Metathesis, Wiley-VCH, Weinheim (b) for a review of M-RCM in natural product synthesis, see Gradillas, A. and Perez-Castells,... 

E. Salceda, J. Perez-Castells, B. Lopez-Mendez, A. Garateix, H. Salazar, O. Lopez, A. Aneiros,... 

The use of RCM in the synthesis of 3,4-carbocyclic indoles was reported by Perez-Castells and co-workers as is exemplified in Scheme 29 <02T5407>. Vinyl indole 49 was quatemized with BnBr and quaternary salt underwent smooth addition of vinyl magnesium bromide to give the indole diene 50. RCM was accomplished with the MC2 in good yields. 

J. Blanco-Urgoiti, D. Abdi, G. Dominguez and J. Perez-Castells, Tetrahedron, 2008, 64, 67. 

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