Percutaneous absorption temperature effects

Skin. The skin may become contaminated accidentally or, in some cases, materials may be deHberately appHed. Skin is a principal route of exposure in the industrial environment. Local effects that are produced include acute or chronic inflammation, allergic reactions, and neoplasia. The skin may also act as a significant route for the absorption of systemicaHy toxic materials. Eactors influencing the amount of material absorbed include the site of contamination, integrity of the skin, temperature, formulation of the material, and physicochemical characteristics, including charge, molecular weight, and hydrophilic and lipophilic characteristics. Determinants of percutaneous absorption and toxicity have been reviewed (32—35,42,43,46—49). 

Ogiso, T, Hirota, T, Masahiro, I., Hino, T. and Tadatoshi, T. (1998) Effect of temperature on percutaneous absorption of terodiline and relationship between penetration and fluidity of stratum corneum lipids . Int. J. Pharm. 176, 63-72. 

Chang, S, K., and Riviere, J, E. (1991). Percutaneous absorption of parathion in vivo in porcine skin. Effects of dose, temperature, humidity and perfusate composidon on absorptive flux. Fundam Appl. Toxicol, 17,494—504. 

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